Guys often wonder whether a dip in testosterone is at the root of their weight gain, says Dr. Stanford. "When men develop overweight and obesity, they tend to have a drop in testosterone that leads to a drop in energy and more retention of adipose tissue,” she says. The excess adipose tissue drives testosterone down. But taking testosterone isn’t usually the answer. “That’s not the underlying problem. Once we normalize the weight, the testosterone normalizes," she explains.