Sometimes the medicines you're taking for other issues, such as high blood pressure and antidepressant meds, can increase your weight or keep you from losing it, says Dr. Stanford. Ask your doctor if your weight concerns could be side effects of the prescriptions you're getting filled. Often, there are other formulations that can be effective but wouldn't have those side effects for you.
Hormonal changes are one of the main reasons that women tend to lose more muscle as they approach menopause. Diet and exercise also play a role.12 On average, adults lose 3 to 8 percent muscle every decade after age 30.13,14 By the time you reach 80, you may have about 30 percent less muscle than you had at age 20.15,16 Muscle loss over time can lead to slower RMR, increased fat, weight gain, weakness, and fractures.17

There appears to be a connection between estrogen and body weight regulation.  With lower estrogen levels, lab animals tend to eat more and be less physically active.  Levels that are too high or too low appear to lead to fat storage.  And, lower estrogen levels may also slow down your metabolic rate (the speed  at your body converts stored energy into working energy).
2. Exercise More. Contrary to what your body may want to do, you must exercise more regularly as you age, not less!  If you’re finding yourself slowing down, gradually start ramping it back up.  It’s not a good idea to go from taking an occasional walk to running a 10K.  That’s a fast track to getting an injury.  But start finding ways to fit more physical activity to your life.  The more you exercise, the more insulin sensitive you become (that’s the opposite of insulin resistant!)
However, the important takeaway here is this: The biggest factor in losing muscle is the lack of physical activity, which makes exercise a crucial component when it comes to preventing muscle loss. If you want to figure out the real deal, enter your information into a calculator to learn how many calories you really need for your age and activity level.
I just hit 40 and decided to make things right for the second 40 ;) I always had a problem with diet and exercises. With diet it's always the same - radical changes, not enough food, recipes are rather complicated and not always tasty. With exercises - if you're not keeping the diet, you can work your ass of everyday and the result will be miserable. Thanks to one book - The Just Cut It Method by Jennifer Morris, I finally understood that the easiest way to lose weight and maintaine better diet is to do it slowly! Lose 50 lbs? Sure but in one year, not in one month! I'm after first month of cleaning my diet and fixing it to my lifestyle, I started to have a longer walks with dog everyday and slowly I'm awakening from the winter sleep ;)
When you were young, you probably didn't spend too much time thinking about preparing your body for the future. In your teens and twenties, you're in peak condition and it's the perfect time to start exercising. Cut to 20 years later and, if you didn't start exercising, you probably wish you had since there's something we all start to experience in our 40's—weight gain.
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